Late Onset Clozapine Induced Agranulocytosis

Biological mechanisms behind clozapine-induced agranulocytosis

HLA associations in clozapine-induced agranulocytosis.

We previously reported preliminary results of association of clozapine-induced agranulocytosis (CA) with HLA-B38, DR4, DQ3 in five Ashkenazi Jewish patients and with HLA-DR2, DQ1 in four non-Jewish patients. In the present study, 31 additional patients with CA, 10 Ashkenazi Jewish, and 21 of non-Jewish ancestry, were studied. HLA alleles and haplotypes were compared among 52 patients (33 Ashken...

Late-onset agranulocytosis in a patient treated with clozapine and lamotrigine.

BACKGROUND Clozapine is the treatment of choice in drug-resistant schizophrenia. Lamotrigine is a mood stabiliser recommended as combined treatment strategy in clozapine-resistant patients. There are cases of late-onset agranulocytosis reported in literature. Some are associated with clozapine or lamotrigine, others with the combination of both. CASE REPORT The article presents a case of rapi...

Agranulocytosis during Clozapine Therapy

Sir, This is in response to the article' Do Indian researchers read Indian research? a reappraisal, four years later', published in April 2000 (No.2, f Vol.42) issue of your journal. The authors of this article have documented their observations on my article 'Transsexualism in Schizophrenia : a case report' (April, 1998, Vol.40, No.2) that I did not refer to their article, 'Behaviour Therapy f...

Clozapine-induced agranulocytosis after 11 years of treatment.

http://ajp.psychiatryonline.org 2. Narendran R, Young CM, Valenti AM, Nickolova MK, Pristach CA: Is psychosis exacerbated by modafinil? (letter). Arch Gen Psychiatry 2002; 59:292–293 3. Spensley J, Rockwell DA: Psychosis during methylphenidate abuse. N Engl J Med 1972; 286:880–881 4. Leong GB, Shaner AL, Silva JA: Narcolepsy, paranoid psychosis, and analeptic abuse. Psychiatr J Univ Ott 1989; 1...